Immunohistochemical investigation of biomarkers for predicting adipose tissue invasion in oral squamous cell carcinoma

The purpose of the present study was to identify histological biomarkers that could be used predict adipose tissue invasion by oral squamous cell carcinoma (OSCC). medical records and preoperative computed tomography scans patients with primary OSCC suspected buccal fat pad were retrospectively reviewed, an immunohistochemical candidate predictive (α-SMA, E-cadherin, N-cadherin, FABP4, Col VI, MMP-11) carried out. Thirty whose tumors in contact based on imaging included this study. Of these, infiltrative histopathologically confirmed 6 (20.0 %). significant higher immunoreactivity detected tumor-buccal area compared tumor surface area.(Pearson’s correlation coefficient test: α-SMA: 0.422, p < 0.05; N-cadherin: 0.476, 0.01; FABP4: 0.467, 0.01;). In area, VI significantly than without (median test, 0.01). Furthermore, high α-SMA expression exhibited a tendency towards association invasion, as did FABP4 = 0.06, 0.07). These results suggest levels may useful for predicting aggressive OSCC.